Protein profile
VK055_1758
molybdate ABC transporter, permease protein
Genome: KpATCC43816
Amino acids
229
Annotations
5
Features
30
PDB binders
0
Druggability
0.838
Overview
Basic information about this protein and its source genome.
- Accession
- VK055_1758
- Gene
- modB AIK80378.1
- Status
- annotated
- Amino acids
- 229
- Structure source
- AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
GO:0015098 Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Human identity (%)
- 0.0
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 67.544
- DEG E-value
- 1.28e-105
- Localization
- CytoplasmicMembrane
- ColabFold pLDDT
- 93.78
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.838
P2Rank
0.224
ColabFold model
Core conservation
Conserved core gene
Gut microbiome
156 / 4744
genomes with a hit
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
5 GO
Gene Ontology (GO)
5- GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
- GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
- GO:0015098 Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid.
- GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
- GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Sequence Features
Domain/signature hits from InterPro and related databases.
30 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 225 | Gene3D | G3DSA:1.10.3720.10 | - |
| 1 | 225 | InterPro | IPR035906 | MetI-like superfamily |
| 136 | 158 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 197 | 219 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 49 | 70 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 19 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 197 | 220 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 26 | 227 | Pfam | PF00528 | Binding-protein-dependent transport system inner membrane component |
| 26 | 227 | InterPro | IPR000515 | ABC transporter type 1, transmembrane domain MetI-like |
| 136 | 158 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 49 | 71 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 2 | 225 | PANTHER | PTHR30183 | MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB |
| 90 | 115 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 159 | 196 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 71 | 89 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 38 | 48 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 86 | 108 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 4 | 220 | SUPERFAMILY | SSF161098 | MetI-like |
| 4 | 220 | InterPro | IPR035906 | MetI-like superfamily |
| 116 | 135 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 20 | 37 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 12 | 221 | NCBIfam | TIGR02141 | molybdate ABC transporter permease subunit |
| 12 | 221 | InterPro | IPR011867 | Molybdenum transport system permease protein ModB |
| 15 | 37 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 12 | 213 | CDD | cd06261 | TM_PBP2 |
| 12 | 213 | InterPro | IPR000515 | ABC transporter type 1, transmembrane domain MetI-like |
| 221 | 229 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 2 | 224 | FunFam | G3DSA:1.10.3720.10:FF:000018 | Molybdenum transport system permease |
| 11 | 214 | ProSiteProfiles | PS50928 | ABC transporter integral membrane type-1 domain profile. |
| 11 | 214 | InterPro | IPR000515 | ABC transporter type 1, transmembrane domain MetI-like |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Legend
High
Medium
Low
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GK73
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
VK055_1758
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 4 | 0.838 | ||||||
| 1 | 0.577 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 5.99 | 0.295 | ||||||
| 2 | 1.88 | 0.037 | ||||||
| 3 | 1.5 | 0.022 | ||||||
| 4 | 1.0 | 0.006 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.815 | ||||||
| 11 | 0.789 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 7.13 | 0.37 | ||||||
| 2 | 2.42 | 0.065 | ||||||
| 3 | 1.44 | 0.019 | ||||||
| 4 | 1.0 | 0.006 |