Protein profile

VK055_1761

molybdenum-pterin binding domain protein

Genome: KpATCC43816

Gene: AIK80381.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ41
Export view
Amino acids 262
Annotations 5
Features 28
PDB binders 0
Druggability 0.116

Overview

Basic information about this protein and its source genome.

Accession
VK055_1761
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80381.1
Status
annotated
Amino acids
262
Structure source
AlphaFold + ColabFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0030151 Binding to a molybdenum ion (Mo). GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.116
Structure A0A0H3GQ41
Pocket Pocket 5
P2Rank
Structure A0A0H3GQ41
Pocket No pockets
ColabFold model
FPocket 0.509 · Pocket 3
P2Rank 0.058 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0030151 Binding to a molybdenum ion (Mo).
  • GO:0015689 The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
125 187 Pfam PF03459 TOBE domain
125 187 InterPro IPR005116 Transport-associated OB, type 1
198 258 Pfam PF03459 TOBE domain
198 258 InterPro IPR005116 Transport-associated OB, type 1
123 192 NCBIfam TIGR00638 molybdenum-pterin binding domain
123 192 InterPro IPR004606 Molybdenum-pterin binding domain
184 252 Gene3D G3DSA:2.40.50.100 -
2 105 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
2 105 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 107 Gene3D G3DSA:1.10.10.10 -
1 107 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
2 178 PANTHER PTHR30432 TRANSCRIPTIONAL REGULATOR MODE
124 191 ProSiteProfiles PS51866 Mop domain profile.
124 191 InterPro IPR004606 Molybdenum-pterin binding domain
123 192 SUPERFAMILY SSF50331 MOP-like
123 192 InterPro IPR008995 Molybdate/tungstate binding, C-terminal
108 183 Gene3D G3DSA:2.40.50.100 -
196 260 ProSiteProfiles PS51866 Mop domain profile.
196 260 InterPro IPR004606 Molybdenum-pterin binding domain
200 259 SUPERFAMILY SSF50331 MOP-like
200 259 InterPro IPR008995 Molybdate/tungstate binding, C-terminal
16 113 NCBIfam TIGR00637 ModE molybdate transport repressor domain
16 113 InterPro IPR003725 Molybdenum-binding protein ModE, N-terminal
1 262 PIRSF PIRSF005763 Txn_reg_ModE
1 262 InterPro IPR016462 Molybdate-dependent transcriptional regulator ModE
1 107 FunFam G3DSA:1.10.10.10:FF:000154 DNA-binding transcriptional regulator ModE
20 83 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family
20 83 InterPro IPR000847 Transcription regulator HTH, LysR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ41
AlphaFold — — full sequence — Viewing
ColabFold VK055_1761
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer