Protein profile

VK055_1787

cyd operon protein YbgE

Genome: KpATCC43816

Gene: AIK80400.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GK47
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Amino acids 96
Annotations 0
Features 17
PDB binders 0
Druggability 0.61

Overview

Basic information about this protein and its source genome.

Accession
VK055_1787
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80400.1
Status
annotated
Amino acids
96
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.61
Structure A0A0H3GK47
Pocket Pocket 1
P2Rank 0.079
Structure A0A0H3GK47
Pocket Pocket 1
ColabFold model
FPocket 0.858 · Pocket 2
P2Rank 0.108 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 108 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
68 73 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
74 95 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 96 NCBIfam TIGR02112 cyd operon protein YbgE
4 96 InterPro IPR011846 Cyd operon protein YbgE
1 17 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
72 94 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 30 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
96 96 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 93 Pfam PF09600 Cyd operon protein YbgE (Cyd_oper_YbgE)
16 93 InterPro IPR011846 Cyd operon protein YbgE
45 67 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
32 39 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
15 33 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 31 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 39 Phobius SIGNAL_PEPTIDE Signal peptide region
49 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
40 48 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GK47
AlphaFold — — full sequence — Viewing
ColabFold VK055_1787
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.61
6 0.087
3 0.025
2 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.0 0.079
2 1.2 0.009