Metabolic network

VK055_1795

dihydrolipoyllysine-residue succinyltransferase,E2 component of oxoglutarate dehydrogenase(succinyl-transferring) complex

Back to protein
Network centrality 0.01023 top 90.9%
Chokepoint Yes

Attractive metabolic target: catalyzes a consuming chokepoint reaction in Citrate cycle (TCA cycle), no isoenzyme backup detected, more central than 90.9% of genes in this genome.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Citrate cycle (TCA cycle) Lipoic acid metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN0-1147

EC 2.3.1.61 · RXN0-1147 · not reversible · no isoenzyme backup

Consuming chokepoint
coenzyme A a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine
→
succinyl-CoA a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine

Imported from KpATCC43816.sbml · 2026-07-09