Protein profile

VK055_1809

allophanate hydrolase subunit 1 family protein

Genome: KpATCC43816

Gene: AIK80422.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLH5
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Amino acids 218
Annotations 2
Features 13
PDB binders 0
Druggability 0.29

Overview

Basic information about this protein and its source genome.

Accession
VK055_1809
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80422.1
Status
annotated
Amino acids
218
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.291
DEG E-value
3.4199999999999997e-68
Localization
Cytoplasmic
ColabFold pLDDT
93.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.29
Structure A0A0H3GLH5
Pocket Pocket 2
P2Rank 0.182
Structure A0A0H3GLH5
Pocket Pocket 1
ColabFold model
FPocket 0.097 · Pocket 3
P2Rank 0.082 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 97 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
9 211 NCBIfam TIGR00370 5-oxoprolinase subunit PxpB
9 211 InterPro IPR010016 5-oxoprolinase subunit B
4 202 SMART SM00796 ahs1
4 202 InterPro IPR003833 Carboxyltransferase domain, subdomain C and D
87 217 Gene3D G3DSA:2.40.100.10 -
87 217 InterPro IPR029000 Cyclophilin-like domain superfamily
89 214 SUPERFAMILY SSF50891 Cyclophilin-like
89 214 InterPro IPR029000 Cyclophilin-like domain superfamily
6 202 Pfam PF02682 Carboxyltransferase domain, subdomain C and D
6 202 InterPro IPR003833 Carboxyltransferase domain, subdomain C and D
5 92 SUPERFAMILY SSF160467 PH0987 N-terminal domain-like
2 215 PANTHER PTHR34698 5-OXOPROLINASE SUBUNIT B
2 215 InterPro IPR010016 5-oxoprolinase subunit B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLH5
AlphaFold — — full sequence — Viewing
ColabFold VK055_1809
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.29
1 0.039
8 0.0
9 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.92 0.182
2 2.03 0.037
3 1.87 0.031
4 0.91 0.004