Protein profile

VK055_1821

seqA, negative modulator of initiation of replication

Genome: KpATCC43816

Gene: AIK80434.1 seqA Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ88
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Amino acids 182
Annotations 5
Features 17
PDB binders 0
Druggability 0.171

Overview

Basic information about this protein and its source genome.

Accession
VK055_1821
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80434.1 seqA
Status
annotated
Amino acids
182
Structure source
AlphaFold + ColabFold
GO
GO:0032297 Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.516
DEG E-value
4.55e-114
Localization
Unknown
ColabFold pLDDT
87.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.171
Structure A0A0H3GQ88
Pocket Pocket 9
P2Rank 0.149
Structure A0A0H3GQ88
Pocket Pocket 1
ColabFold model
FPocket 0.253 · Pocket 6
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0032297 Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 182 Hamap MF_00908 Negative modulator of initiation of replication [seqA].
1 182 InterPro IPR005621 Negative modulator of initiation of replication SeqA
66 182 Gene3D G3DSA:1.20.1380.10 -
66 182 InterPro IPR036835 Replication modulator SeqA, C-terminal DNA-binding domain superfamily
1 35 SUPERFAMILY SSF47598 Ribbon-helix-helix
1 35 InterPro IPR010985 Ribbon-helix-helix
72 180 Pfam PF03925 SeqA protein C-terminal domain
72 180 InterPro IPR026577 Replication modulator SeqA, C-terminal DNA-binding domain
1 36 Pfam PF17206 SeqA protein N-terminal domain
1 36 InterPro IPR033761 Negative modulator of initiation of replication SeqA, N-terminal
1 182 PIRSF PIRSF019401 SeqA
67 182 SUPERFAMILY SSF82808 Replication modulator SeqA, C-terminal DNA-binding domain
67 182 InterPro IPR036835 Replication modulator SeqA, C-terminal DNA-binding domain superfamily
1 41 Gene3D G3DSA:1.10.1220.10 -
1 41 InterPro IPR013321 Arc-type ribbon-helix-helix
1 41 FunFam G3DSA:1.10.1220.10:FF:000002 Negative modulator of initiation of replication
66 182 FunFam G3DSA:1.20.1380.10:FF:000001 Negative modulator of initiation of replication

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ88
AlphaFold — — full sequence — Viewing
ColabFold VK055_1821
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer