Protein profile

VK055_1859

rare lipoprotein LptE

Genome: KpATCC43816

Gene: AIK80465.1 Structure source: ColabFold
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Amino acids 164
Annotations 2
Features 8
PDB binders 0
Druggability 0.197

Overview

Basic information about this protein and its source genome.

Accession
VK055_1859
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80465.1
Status
annotated
Amino acids
164
Structure source
ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
75.926
DEG E-value
9.66e-87
Localization
OuterMembrane
ColabFold pLDDT
88.76

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.197
Structure CB_VK055_1859
Pocket Pocket 8
P2Rank
Structure CB_VK055_1859
Pocket No pockets
ColabFold model
FPocket 0.197 · Pocket 8
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 86 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
134 164 MobiDBLite mobidb-lite consensus disorder prediction
12 127 Pfam PF04390 Lipopolysaccharide-assembly
12 127 InterPro IPR007485 LPS-assembly lipoprotein LptE
1 132 Hamap MF_01186 LPS-assembly lipoprotein LptE [lptE].
1 132 InterPro IPR007485 LPS-assembly lipoprotein LptE
1 153 PANTHER PTHR38098 LPS-ASSEMBLY LIPOPROTEIN LPTE
1 153 InterPro IPR007485 LPS-assembly lipoprotein LptE
1 137 Gene3D G3DSA:3.30.160.150 Lipoprotein like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed ColabFold model VK055_1859 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_1859
ColabFold — — full sequence — Viewing