Protein profile

VK055_1949

ykfE inhibitor of vertebrate C-type lysozyme

Genome: KpATCC43816

Gene: ykfE AIK80555.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPM4
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Amino acids 148
Annotations 2
Features 14
PDB binders 0
Druggability 0.266

Overview

Basic information about this protein and its source genome.

Accession
VK055_1949
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
ykfE AIK80555.1
Status
annotated
Amino acids
148
Structure source
AlphaFold + ColabFold
GO
GO:0043086 Any process that stops or reduces the activity of an enzyme. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
89.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.266
Structure A0A0H3GPM4
Pocket Pocket 1
P2Rank 0.024
Structure A0A0H3GPM4
Pocket Pocket 1
ColabFold model
FPocket 0.266 · Pocket 2
P2Rank 0.005 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0043086 Any process that stops or reduces the activity of an enzyme.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 145 PIRSF PIRSF009103 Ivy
1 145 InterPro IPR014453 Inhibitor of vertebrate lysozyme
20 148 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
30 143 Pfam PF08816 Inhibitor of vertebrate lysozyme (Ivy)
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
20 148 Gene3D G3DSA:3.40.1420.10 Inhibitor of vertebrate lysozyme
20 148 InterPro IPR036501 Inhibitor of vertebrate lysozyme superfamily
22 147 SUPERFAMILY SSF89872 Inhibitor of vertebrate lysozyme, Ivy
22 147 InterPro IPR036501 Inhibitor of vertebrate lysozyme superfamily
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPM4
AlphaFold — — full sequence — Viewing
ColabFold VK055_1949
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.266
4 0.211