Protein profile

VK055_1954

acetyltransferase family protein

Genome: KpATCC43816

Gene: AIK80560.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPM1
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Amino acids 231
Annotations 4
Features 9
PDB binders 0
Druggability 0.034

Overview

Basic information about this protein and its source genome.

Accession
VK055_1954
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80560.1
Status
annotated
Amino acids
231
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990189 Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein]. GO:0008999 Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein].

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
26.163
Localization
Cytoplasmic
ColabFold pLDDT
97.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.034
Structure A0A0H3GPM1
Pocket Pocket 14
P2Rank 0.914
Structure A0A0H3GPM1
Pocket Pocket 1
ColabFold model
FPocket 0.093 · Pocket 13
P2Rank 0.929 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:1990189 Catalysis of the reaction: acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nalpha-acetyl-L-seryl-[protein].
  • GO:0008999 Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal N(alpha)-acetyl-L-alanyl-[protein].

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
34 190 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
34 190 InterPro IPR000182 GNAT domain
28 197 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
28 197 InterPro IPR016181 Acyl-CoA N-acyltransferase
16 231 Gene3D G3DSA:3.40.630.30 -
17 231 FunFam G3DSA:3.40.630.30:FF:000047 Acetyltransferase, GNAT family
36 172 Pfam PF13302 Acetyltransferase (GNAT) domain
36 172 InterPro IPR000182 GNAT domain
18 204 PANTHER PTHR43441 RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPM1
AlphaFold — — full sequence — Viewing
ColabFold VK055_1954
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.93 0.832
2 2.03 0.045