Protein profile

VK055_1972

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK80578.1 Structure source: AlphaFold + ColabFold UniProt W9BNL8
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Amino acids 297
Annotations 3
Features 30
PDB binders 0
Druggability 0.724

Overview

Basic information about this protein and its source genome.

Accession
VK055_1972
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80578.1
Status
annotated
Amino acids
297
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
66.323
DEG E-value
7.89e-138
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.724
Structure W9BNL8
Pocket Pocket 1
P2Rank 0.091
Structure W9BNL8
Pocket Pocket 1
ColabFold model
FPocket 0.743 · Pocket 16
P2Rank 0.105 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
1 36 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
146 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
37 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 58 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 294 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
59 98 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
242 260 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
105 127 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
261 286 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 286 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
97 286 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
260 282 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
115 290 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
115 290 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
214 241 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
287 297 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
92 279 SUPERFAMILY SSF161098 MetI-like
92 279 InterPro IPR035906 MetI-like superfamily
127 145 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
87 294 Gene3D G3DSA:1.10.3720.10 -
87 294 InterPro IPR035906 MetI-like superfamily
98 278 CDD cd06261 TM_PBP2
98 278 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
139 161 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 63 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
22 63 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
99 126 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
194 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
218 240 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
173 213 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W9BNL8
AlphaFold — — full sequence — Viewing
ColabFold VK055_1972
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.724
2 0.513
8 0.218

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.66 0.138
2 2.88 0.091
3 1.66 0.028
4 1.18 0.01
5 1.06 0.007