Metabolic network

VK055_2067

UDP-2,3-diacylglucosamine hydrolase

Back to protein
Network centrality 0
Chokepoint Yes

Attractive metabolic target: catalyzes a producing chokepoint reaction in Lipopolysaccharide biosynthesis, no isoenzyme backup detected, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Lipopolysaccharide biosynthesis

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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EC
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Pathway
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Genes
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

LIPIDXSYNTHESIS-RXN

EC 3.6.1.54 · LIPIDXSYNTHESIS-RXN · not reversible · no isoenzyme backup

H2O UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
→
2 H+ lipid X (E. coli) UMP

RXN2B4Q-51

EC 3.6.1.54 · RXN2B4Q-51 · not reversible · no isoenzyme backup

UDP-2-N-[(3R)-3-hydroxydodecanoyl]-3-N-[(3R)-3-hydroxyhexanoyl]-alpha-3-amino-3-deoxy-D-glucosamine H2O
→
lipid X (Brucella) UMP 2 H+

RXN-20786

EC 3.6.1.54 · RXN-20786 · not reversible · no isoenzyme backup

UDP-2-N-[(3R)-3-hydroxydodecanoyl]-3-O-[(3R)-3-hydroxydecanoyl]-alpha-D-glucosamine H2O
→
lipid X (P. putida) UMP 2 H+

RXN2DNV-1

EC 3.6.1.54 · RXN2DNV-1 · not reversible · no isoenzyme backup

UDP-2-N-[(3R)-3-hydroxyoctadecanoyl]-3-O-[(3R)-3-hydroxyhexadecanoyl]-alpha-D-glucosamine H2O
→
lipid X (H. pylori) UMP 2 H+

RXN-23220

EC 3.6.1.54 · RXN-23220 · not reversible · no isoenzyme backup

Producing chokepoint
UDP-2-N-[(3R)-3-hydroxytetradecanoyl]-3-O-[(3R)-3-hydroxydodecanoyl]-alpha-D-glucosamine H2O
→
lipid X (Vibrio cholerae serogroup O1 El Tor) UMP 2 H+

RXN-22239

EC 3.6.1.54 · RXN-22239 · not reversible · no isoenzyme backup

Producing & consuming chokepoint
UDP-2-N-[(3R)-3-hydroxy-16-methylhexadecanoyl]-3-O-[(3R)-3-hydroxyhexadecanoyl]-alpha-D-glucosamine H2O
→
lipid X (P. gingivalis) UMP 2 H+

Imported from KpATCC43816.sbml · 2026-07-09