Protein profile

VK055_2083

nfeD-like C-terminal, partner-binding family protein

Genome: KpATCC43816

Gene: AIK80687.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP64
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Amino acids 152
Annotations 0
Features 16
PDB binders 0
Druggability 0.407

Overview

Basic information about this protein and its source genome.

Accession
VK055_2083
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80687.1
Status
annotated
Amino acids
152
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.14

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.407
Structure A0A0H3GP64
Pocket Pocket 6
P2Rank 0.039
Structure A0A0H3GP64
Pocket Pocket 1
ColabFold model
FPocket 0.618 · Pocket 9
P2Rank 0.045 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
55 72 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
40 54 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 150 PANTHER PTHR33507 INNER MEMBRANE PROTEIN YBBJ
49 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 151 FunFam G3DSA:2.40.50.140:FF:000118 NfeD family protein
1 39 Phobius SIGNAL_PEPTIDE Signal peptide region
90 151 Gene3D G3DSA:2.40.50.140 -
90 151 InterPro IPR012340 Nucleic acid-binding, OB-fold
59 149 Pfam PF01957 NfeD-like C-terminal, partner-binding
59 149 InterPro IPR002810 NfeD-like, C-terminal domain
22 39 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
107 149 SUPERFAMILY SSF141322 NfeD domain-like
73 152 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP64
AlphaFold — — full sequence — Viewing
ColabFold VK055_2083
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.174
8 0.099
3 0.023
7 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.08 0.039