Protein profile

VK055_2207

amidohydrolase family protein

Genome: KpATCC43816

Gene: AIK80812.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSK8
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Amino acids 622
Annotations 1
Features 13
PDB binders 0
Druggability 0.886

Overview

Basic information about this protein and its source genome.

Accession
VK055_2207
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80812.1
Status
annotated
Amino acids
622
Structure source
AlphaFold + ColabFold
GO
GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
62.54
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.886
Structure A0A0H3GSK8
Pocket Pocket 19
P2Rank 0.937
Structure A0A0H3GSK8
Pocket Pocket 1
ColabFold model
FPocket 0.871 · Pocket 10
P2Rank 0.947 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
26 507 CDD cd01300 YtcJ_like
26 507 InterPro IPR033932 YtcJ like
83 206 Gene3D G3DSA:3.10.310.70 -
52 536 Pfam PF07969 Amidohydrolase family
52 536 InterPro IPR013108 Amidohydrolase 3
2 544 SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases
2 544 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
3 538 PANTHER PTHR22642 IMIDAZOLONEPROPIONASE
12 511 Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1
12 511 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
64 495 Gene3D G3DSA:3.20.20.140 -
63 496 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
63 496 InterPro IPR032466 Metal-dependent hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSK8
AlphaFold — — full sequence — Viewing
ColabFold VK055_2207
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
19 0.886

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.29 0.93
2 4.68 0.204
3 1.72 0.03
4 1.0 0.006