Protein profile

VK055_2262

gram-negative pili assembly chaperone, N-terminal domain protein

Genome: KpATCC43816

Gene: AIK80867.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSF8
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Amino acids 224
Annotations 2
Features 13
PDB binders 0
Druggability 0.443

Overview

Basic information about this protein and its source genome.

Accession
VK055_2262
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80867.1
Status
annotated
Amino acids
224
Structure source
AlphaFold + ColabFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.5
DEG E-value
4.38e-150
Localization
Unknown
ColabFold pLDDT
89.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.443
Structure A0A0H3GSF8
Pocket Pocket 1
P2Rank 0.083
Structure A0A0H3GSF8
Pocket Pocket 1
ColabFold model
FPocket 0.356 · Pocket 1
P2Rank 0.074 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
12 115 SUPERFAMILY SSF49354 PapD-like
12 115 InterPro IPR008962 PapD-like superfamily
16 143 Pfam PF00345 Pili and flagellar-assembly chaperone, PapD N-terminal domain
16 143 InterPro IPR016147 Pili assembly chaperone, N-terminal
1 15 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
16 139 Gene3D G3DSA:2.60.40.10 Immunoglobulins
16 139 InterPro IPR013783 Immunoglobulin-like fold
1 29 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
16 224 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
11 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSF8
AlphaFold — — full sequence — Viewing
ColabFold VK055_2262
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.038
9 0.001
4 0.0
5 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.1 0.083
2 2.12 0.04