Protein profile

VK055_2265

hypothetical protein

Genome: KpATCC43816

Gene: AIK80870.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN88
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Amino acids 222
Annotations 0
Features 13
PDB binders 0
Druggability 0.268

Overview

Basic information about this protein and its source genome.

Accession
VK055_2265
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80870.1
Status
annotated
Amino acids
222
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.122
Localization
Unknown
ColabFold pLDDT
90.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.268
Structure A0A0H3GN88
Pocket Pocket 6
P2Rank 0.042
Structure A0A0H3GN88
Pocket Pocket 1
ColabFold model
FPocket 0.302 · Pocket 3
P2Rank 0.059 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
20 116 SUPERFAMILY SSF49354 PapD-like
20 116 InterPro IPR008962 PapD-like superfamily
21 222 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
150 221 Pfam PF18649 EcpB C-terminal domain
150 221 InterPro IPR040695 EcpB, C-terminal
21 143 Gene3D G3DSA:2.60.40.10 Immunoglobulins
21 143 InterPro IPR013783 Immunoglobulin-like fold
1 20 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN88
AlphaFold — — full sequence — Viewing
ColabFold VK055_2265
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.015
3 0.013
1 0.0
8 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.17 0.042
2 1.48 0.017