Protein profile

VK055_2290

fimbrial subunit type 1

Genome: KpATCC43816

Gene: fim AIK80894.1 Structure source: ColabFold
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Amino acids 126
Annotations 2
Features 7
PDB binders 0
Druggability 0.329

Overview

Basic information about this protein and its source genome.

Accession
VK055_2290
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
fim AIK80894.1
Status
annotated
Amino acids
126
Structure source
ColabFold
GO
GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
60.8
DEG E-value
7.25e-46
Localization
Extracellular
ColabFold pLDDT
93.39

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.329
Structure CB_VK055_2290
Pocket Pocket 4
P2Rank 0.199
Structure CB_VK055_2290
Pocket Pocket 1
ColabFold model
FPocket 0.329 · Pocket 4
P2Rank 0.199 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 29 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
1 126 Pfam PF00419 Fimbrial protein
1 126 InterPro IPR000259 Fimbrial-type adhesion domain
1 126 PANTHER PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
1 126 SUPERFAMILY SSF49401 Bacterial adhesins
1 126 InterPro IPR008966 Adhesion domain superfamily
1 126 Gene3D G3DSA:2.60.40.1090 -
1 126 InterPro IPR036937 Fimbrial-type adhesion domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_2290
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.329
3 0.012
2 0.005
1 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.2 0.199
2 1.65 0.023