Protein profile

VK055_2327

ubiquinone oxidoreductase, Na(+)-translocating, A subunit

Genome: KpATCC43816

Gene: nqrA AIK80931.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJV1
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Amino acids 447
Annotations 3
Features 10
PDB binders 0
Druggability 0.487

Overview

Basic information about this protein and its source genome.

Accession
VK055_2327
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
nqrA AIK80931.1
Status
annotated
Amino acids
447
Structure source
AlphaFold + ColabFold
EC
7.2.1.1
GO
GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.487
Structure A0A0H3GJV1
Pocket Pocket 28
P2Rank 0.882
Structure A0A0H3GJV1
Pocket Pocket 1
ColabFold model
FPocket 0.558 · Pocket 6
P2Rank 0.88 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 115 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 447 PANTHER PTHR37839 NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A
1 447 InterPro IPR008703 Na(+)-translocating NADH-quinone reductase subunit A
262 311 Pfam PF11973 NQRA C-terminal domain
262 311 InterPro IPR022615 Na(+)-translocating NADH-quinone reductase subunit A, C-terminal domain
42 90 Gene3D G3DSA:2.40.50.100 -
1 447 Hamap MF_00425 Na(+)-translocating NADH-quinone reductase subunit A [nqrA].
1 257 Pfam PF05896 Na(+)-translocating NADH-quinone reductase subunit A (NQRA)
1 257 InterPro IPR008703 Na(+)-translocating NADH-quinone reductase subunit A
2 447 NCBIfam TIGR01936 NADH:ubiquinone reductase (Na(+)-transporting) subunit A
2 447 InterPro IPR008703 Na(+)-translocating NADH-quinone reductase subunit A

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJV1
AlphaFold — — full sequence — Viewing
ColabFold VK055_2327
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
28 0.487
7 0.008
30 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.38 0.882
2 9.92 0.459
3 2.84 0.071
4 1.14 0.008
5 0.92 0.004