Protein profile

VK055_2342

endonuclease/Exonuclease/phosphatase family protein

Genome: KpATCC43816

Gene: AIK80945.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS88
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Amino acids 258
Annotations 3
Features 8
PDB binders 0
Druggability 0.178

Overview

Basic information about this protein and its source genome.

Accession
VK055_2342
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80945.1
Status
annotated
Amino acids
258
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.76
DEG E-value
3.79e-176
Localization
Unknown
ColabFold pLDDT
88.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.178
Structure A0A0H3GS88
Pocket Pocket 21
P2Rank 0.7
Structure A0A0H3GS88
Pocket Pocket 1
ColabFold model
FPocket 0.296 · Pocket 6
P2Rank 0.619 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
42 245 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family
42 245 InterPro IPR005135 Endonuclease/exonuclease/phosphatase
1 253 Hamap MF_01119 UPF0294 protein YafD [yafD].
1 253 InterPro IPR022958 Uncharacterised protein family UPF0294
37 253 SUPERFAMILY SSF56219 DNase I-like
37 253 InterPro IPR036691 Endonuclease/exonuclease/phosphatase superfamily
35 254 Gene3D G3DSA:3.60.10.10 Endonuclease/exonuclease/phosphatase
35 254 InterPro IPR036691 Endonuclease/exonuclease/phosphatase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS88
AlphaFold — — full sequence — Viewing
ColabFold VK055_2342
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.38 0.649
2 2.14 0.05