Protein profile

VK055_2359

nlpC/P60 family protein

Genome: KpATCC43816

Gene: AIK80956.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJS7
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Amino acids 280
Annotations 0
Features 14
PDB binders 0
Druggability 0.319

Overview

Basic information about this protein and its source genome.

Accession
VK055_2359
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80956.1
Status
annotated
Amino acids
280
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.319
Structure A0A0H3GJS7
Pocket Pocket 9
P2Rank 0.681
Structure A0A0H3GJS7
Pocket Pocket 1
ColabFold model
FPocket 0.443 · Pocket 16
P2Rank 0.928 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 14 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 35 Phobius SIGNAL_PEPTIDE Signal peptide region
10 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 28 SignalP_EUK SignalP-noTM SignalP-noTM
1 35 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
64 262 SUPERFAMILY SSF54001 Cysteine proteinases
64 262 InterPro IPR038765 Papain-like cysteine peptidase superfamily
36 280 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 35 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
58 243 Gene3D G3DSA:3.90.1720.10 endopeptidase domain like (from Nostoc punctiforme)
65 155 Pfam PF05708 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
65 155 InterPro IPR024453 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJS7
AlphaFold — — full sequence — Viewing
ColabFold VK055_2359
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.076
6 0.021
15 0.004
14 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.77 0.681
2 10.74 0.495
3 5.2 0.198
4 3.09 0.083
5 2.6 0.061