Protein profile

VK055_2360

nlpE N-terminal domain protein

Genome: KpATCC43816

Gene: AIK80957.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNN5
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Amino acids 232
Annotations 0
Features 17
PDB binders 0
Druggability 0.436

Overview

Basic information about this protein and its source genome.

Accession
VK055_2360
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80957.1
Status
annotated
Amino acids
232
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
87.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.436
Structure A0A0H3GNN5
Pocket Pocket 2
P2Rank 0.22
Structure A0A0H3GNN5
Pocket Pocket 1
ColabFold model
FPocket 0.416 · Pocket 1
P2Rank 0.325 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 71 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
144 232 Gene3D G3DSA:2.40.50.540 -
144 232 InterPro IPR038139 NlpE, C-terminal domain superfamily
1 20 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
44 128 Pfam PF04170 NlpE N-terminal domain
44 128 InterPro IPR007298 Copper resistance lipoprotein NlpE
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
19 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
20 117 Gene3D G3DSA:2.40.128.300 -
20 117 InterPro IPR043176 NlpE, N-terminal domain superfamily
27 232 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 SignalP_EUK SignalP-noTM SignalP-noTM
4 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
143 231 Pfam PF17185 NlpE C-terminal OB domain
143 231 InterPro IPR033450 NlpE, C-terminal OB domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNN5
AlphaFold — — full sequence — Viewing
ColabFold VK055_2360
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.016
10 0.002
5 0.0
13 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.55 0.22
2 5.22 0.2
3 1.34 0.013