Metabolic network

VK055_2370

lipid-A-disaccharide synthase

Back to protein
Network centrality 0.0295 top 93.7%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing & consuming chokepoint reaction in Lipopolysaccharide biosynthesis, no isoenzyme backup detected, more central than 93.7% of genes in this genome, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Lipopolysaccharide biosynthesis

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN-23219

EC 2.4.1.182 · RXN-23219 · not reversible · no isoenzyme backup

lipid X (Vibrio cholerae serogroup O1 El Tor) UDP-2-N-[(3R)-3-hydroxytetradecanoyl]-3-O-[(3R)-3-hydroxydodecanoyl]-alpha-D-glucosamine
→
lipid A disaccharide (Vibrio cholerae serogroup O1 El Tor) UDP H+

RXN-22237

EC 2.4.1.182 · RXN-22237 · not reversible · no isoenzyme backup

lipid X (P. gingivalis) UDP-2-N-[(3R)-3-hydroxy-15-methylhexadecanoyl]-3-O-[(3R)-3-hydroxy-13-methyltetradecanoyl]-alpha-D-glucosamine
→
lipid A disaccharide (P. gingivalis) UDP H+

RXN2DNV-2

EC 2.4.1.182 · RXN2DNV-2 · not reversible · no isoenzyme backup

lipid X (H. pylori) UDP-2-N-[(3R)-3-hydroxyoctadecanoyl]-3-O-[(3R)-3-hydroxyhexadecanoyl]-alpha-D-glucosamine
→
lipid A disaccharide (H. pylori) UDP H+

RXN2B4Q-52

EC 2.4.1.182 · RXN2B4Q-52 · not reversible · no isoenzyme backup

lipid X (Brucella) UDP-2-N-[(3R)-3-hydroxydodecanoyl]-3-N-[(3R)-3-hydroxyhexanoyl]-alpha-3-amino-3-deoxy-D-glucosamine
→
dephospho-lipid IVA (Brucella) UDP H+

RXN-20785

EC 2.4.1.182 · RXN-20785 · not reversible · no isoenzyme backup

Producing & consuming chokepoint
lipid X (P. putida) UDP-2-N-[(3R)-3-hydroxydodecanoyl]-3-O-[(3R)-3-hydroxydecanoyl]-alpha-D-glucosamine
→
lipid A disaccharide (P. putida) UDP H+

Imported from KpATCC43816.sbml · 2026-07-09