Protein profile

VK055_2374

periplasmic chaperone

Genome: KpATCC43816

Gene: hlpA AIK80971.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJP1
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Amino acids 148
Annotations 4
Features 13
PDB binders 0
Druggability 0.193

Overview

Basic information about this protein and its source genome.

Accession
VK055_2374
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
hlpA AIK80971.1
Status
annotated
Amino acids
148
Structure source
AlphaFold + ColabFold
GO
GO:0051082 Binding to an unfolded protein. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0050821 Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
90.411
DEG E-value
1.8199999999999998e-92
Localization
Periplasmic
ColabFold pLDDT
94.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.193
Structure A0A0H3GJP1
Pocket Pocket 2
P2Rank 0.004
Structure A0A0H3GJP1
Pocket Pocket 1
ColabFold model
FPocket 0.403 · Pocket 5
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0051082 Binding to an unfolded protein.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0050821 Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
6 148 Gene3D G3DSA:3.30.910.20 Skp domain
6 148 InterPro IPR024930 Skp domain superfamily
6 148 FunFam G3DSA:3.30.910.20:FF:000001 Molecular chaperone Skp
3 148 PANTHER PTHR35089 CHAPERONE PROTEIN SKP
3 148 InterPro IPR005632 Chaperone protein Skp
10 146 Pfam PF03938 Outer membrane protein (OmpH-like)
10 146 InterPro IPR005632 Chaperone protein Skp
81 101 MobiDBLite mobidb-lite consensus disorder prediction
1 148 SMART SM00935 OmpH_2
1 148 InterPro IPR005632 Chaperone protein Skp
1 148 PIRSF PIRSF002094 OMP26_Skp
7 147 SUPERFAMILY SSF111384 OmpH-like
7 147 InterPro IPR024930 Skp domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJP1
AlphaFold — — full sequence — Viewing
ColabFold VK055_2374
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer