Protein profile

VK055_2377

cytidylyltransferase family protein

Genome: KpATCC43816

Gene: AIK80974.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIJ8
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Amino acids 285
Annotations 6
Features 33
PDB binders 0
Druggability 0.737

Overview

Basic information about this protein and its source genome.

Accession
VK055_2377
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK80974.1
Status
annotated
Amino acids
285
Structure source
AlphaFold + ColabFold
EC
2.7.7.41
GO
GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004605 Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. GO:0016024 The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
30.588
Human E-value
2.37e-10
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.421
DEG E-value
4.29e-175
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737
Structure A0A0H3GIJ8
Pocket Pocket 1
P2Rank 0.906
Structure A0A0H3GIJ8
Pocket Pocket 1
ColabFold model
FPocket 0.903 · Pocket 10
P2Rank 0.94 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004605 Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
  • GO:0016024 The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
7 41 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 282 PANTHER PTHR46382 PHOSPHATIDATE CYTIDYLYLTRANSFERASE
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
239 265 ProSitePatterns PS01315 Phosphatidate cytidylyltransferase signature.
239 265 InterPro IPR000374 Phosphatidate cytidylyltransferase
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
189 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 113 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
56 78 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
74 92 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
237 263 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
264 282 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
114 119 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
19 27 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
219 236 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
56 73 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
218 240 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 55 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
193 213 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 279 Pfam PF01148 Cytidylyltransferase family
28 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
173 192 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
260 282 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
120 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
153 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
283 285 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
118 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
214 218 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
91 113 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
147 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
142 152 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIJ8
AlphaFold — — full sequence — Viewing
ColabFold VK055_2377
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.737
2 0.669

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.34 0.88
2 9.26 0.497
3 4.9 0.22
4 3.38 0.12
5 1.77 0.033