Protein profile

VK055_2385

protein-P-II uridylyltransferase

Genome: KpATCC43816

Gene: glnD AIK80982.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNI7
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Amino acids 867
Annotations 6
Features 41
PDB binders 0
Druggability 0.586

Overview

Basic information about this protein and its source genome.

Accession
VK055_2385
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
glnD AIK80982.1
Status
annotated
Amino acids
867
Structure source
AlphaFold + ColabFold
GO
GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0008893 Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+. GO:0008081 Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006808 Any process that modulates the frequency, rate or extent of nitrogen utilization.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.671
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.586
Structure A0A0H3GNI7
Pocket Pocket 9
P2Rank 0.823
Structure A0A0H3GNI7
Pocket Pocket 1
ColabFold model
FPocket 0.436 · Pocket 9
P2Rank 0.86 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII).
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
  • GO:0008893 Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H+.
  • GO:0008081 Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
  • GO:0006808 Any process that modulates the frequency, rate or extent of nitrogen utilization.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
793 867 ProSiteProfiles PS51671 ACT domain profile.
793 867 InterPro IPR002912 ACT domain
686 761 ProSiteProfiles PS51671 ACT domain profile.
686 761 InterPro IPR002912 ACT domain
1 867 Hamap MF_00277 Bifunctional uridylyltransferase/uridylyl-removing enzyme [glnD].
1 867 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
684 755 CDD cd04900 ACT_UUR-like_1
682 755 SUPERFAMILY SSF55021 ACT-like
682 755 InterPro IPR045865 ACT-like domain
3 866 PIRSF PIRSF006288 PII_uridyltransf
3 866 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
792 850 SUPERFAMILY SSF55021 ACT-like
792 850 InterPro IPR045865 ACT-like domain
443 595 CDD cd00077 HDc
443 595 InterPro IPR003607 HD/PDEase domain
794 851 Pfam PF01842 ACT domain
794 851 InterPro IPR002912 ACT domain
686 739 Pfam PF01842 ACT domain
686 739 InterPro IPR002912 ACT domain
434 576 Gene3D G3DSA:1.10.3210.10 Hypothetical protein af1432
57 124 Pfam PF01909 Nucleotidyltransferase domain
57 124 InterPro IPR002934 Polymerase, nucleotidyl transferase domain
24 160 CDD cd05401 NT_GlnE_GlnD_like
794 861 CDD cd04899 ACT_ACR-UUR-like_2
8 865 PANTHER PTHR47320 BIFUNCTIONAL URIDYLYLTRANSFERASE/URIDYLYL-REMOVING ENZYME
8 865 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
441 588 SMART SM00471 hd_13
441 588 InterPro IPR003607 HD/PDEase domain
189 305 SUPERFAMILY SSF81593 Nucleotidyltransferase substrate binding subunit/domain
445 578 Pfam PF01966 HD domain
445 578 InterPro IPR006674 HD domain
434 577 SUPERFAMILY SSF109604 HD-domain/PDEase-like
35 165 SUPERFAMILY SSF81301 Nucleotidyltransferase
35 165 InterPro IPR043519 Nucleotidyltransferase superfamily
445 567 ProSiteProfiles PS51831 HD domain profile.
445 567 InterPro IPR006674 HD domain
170 308 Pfam PF08335 GlnD PII-uridylyltransferase
170 308 InterPro IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
32 861 NCBIfam TIGR01693 [protein-PII] uridylyltransferase
32 861 InterPro IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme
434 576 FunFam G3DSA:1.10.3210.10:FF:000005 Bifunctional uridylyltransferase/uridylyl-removing enzyme

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNI7
AlphaFold — — full sequence — Viewing
ColabFold VK055_2385
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.481
1 0.098
18 0.0
37 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.19 0.823
2 20.16 0.789
3 18.58 0.755
4 11.4 0.526
5 10.53 0.486