Protein profile

VK055_2467

hypothetical protein

Genome: KpATCC43816

Gene: AIK81064.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GI82
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Amino acids 64
Annotations 3
Features 10
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
VK055_2467
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81064.1
Status
annotated
Amino acids
64
Structure source
AlphaFold + ColabFold
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket
Structure A0A0H3GI82
Pocket No pockets
P2Rank
Structure A0A0H3GI82
Pocket No pockets
ColabFold model
FPocket 0.327 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 164 / 4744 genomes with a hit
Normalized 0.035

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 63 PANTHER PTHR36150 DNA GYRASE INHIBITOR YACG
1 63 InterPro IPR005584 DNA gyrase inhibitor YacG
7 57 Pfam PF03884 DNA gyrase inhibitor YacG
7 57 InterPro IPR005584 DNA gyrase inhibitor YacG
45 64 MobiDBLite mobidb-lite consensus disorder prediction
3 62 SUPERFAMILY SSF57716 Glucocorticoid receptor-like (DNA-binding domain)
3 59 Hamap MF_00649 DNA gyrase inhibitor YacG [yacG].
3 59 InterPro IPR005584 DNA gyrase inhibitor YacG
1 64 Gene3D G3DSA:3.30.50.10 -
1 64 InterPro IPR013088 Zinc finger, NHR/GATA-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GI82
AlphaFold — — full sequence — Viewing
ColabFold VK055_2467
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer