Protein profile

VK055_2470

secretion monitor family protein

Genome: KpATCC43816

Gene: AIK81067.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN99
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Amino acids 165
Annotations 3
Features 12
PDB binders 0
Druggability 0.898

Overview

Basic information about this protein and its source genome.

Accession
VK055_2470
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81067.1
Status
annotated
Amino acids
165
Structure source
AlphaFold + ColabFold
GO
GO:0045182 Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
73.837
DEG E-value
1.45e-80
Localization
Cytoplasmic
ColabFold pLDDT
60.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.898
Structure A0A0H3GN99
Pocket Pocket 10
P2Rank
Structure A0A0H3GN99
Pocket No pockets
ColabFold model
FPocket 0.492 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 81 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0045182 Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
24 162 Pfam PF06558 Secretion monitor precursor protein (SecM)
24 162 InterPro IPR009502 Secretion monitor
1 165 Hamap MF_01332 Secretion monitor [secM].
1 165 InterPro IPR009502 Secretion monitor
38 165 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 27 SignalP_EUK SignalP-noTM SignalP-noTM
32 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 165 PIRSF PIRSF004572 SecM
20 31 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN99
AlphaFold — — full sequence — Viewing
ColabFold VK055_2470
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.898