Protein profile

VK055_2507

thiamine/thiamine pyrophosphate ABC transporter,permease protein

Genome: KpATCC43816

Gene: AIK81104.1 thiP Structure source: AlphaFold + ColabFold UniProt A0A0H3GJ62
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Amino acids 523
Annotations 5
Features 62
PDB binders 0
Druggability 0.732

Overview

Basic information about this protein and its source genome.

Accession
VK055_2507
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81104.1 thiP
Status
annotated
Amino acids
523
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015888 The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.725
DEG E-value
4.7e-123
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.732
Structure A0A0H3GJ62
Pocket Pocket 4
P2Rank 0.905
Structure A0A0H3GJ62
Pocket Pocket 1
ColabFold model
FPocket 0.894 · Pocket 1
P2Rank 0.894 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015888 The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

62 records
Show feature table
Start End DB Term Name
228 247 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
394 411 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
382 392 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
45 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
124 146 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
412 451 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
185 207 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
279 301 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
362 381 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 248 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
39 248 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
2 512 NCBIfam TIGR01253 thiamine/thiamine pyrophosphate ABC transporter permease
2 512 InterPro IPR005947 Thiamine ABC transporter, permease protein
208 226 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
513 523 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
302 320 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 35 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
186 208 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
342 361 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
279 514 SUPERFAMILY SSF161098 MetI-like
279 514 InterPro IPR035906 MetI-like superfamily
1 35 Phobius SIGNAL_PEPTIDE Signal peptide region
78 104 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
321 343 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
360 379 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
44 242 CDD cd06261 TM_PBP2
44 242 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
67 77 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
105 123 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
227 247 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
147 184 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 256 FunFam G3DSA:1.10.3720.10:FF:000044 Thiamine/thiamine pyrophosphate ABC transporter permease ThiP
280 301 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 255 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
61 255 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
476 494 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 252 SUPERFAMILY SSF161098 MetI-like
6 252 InterPro IPR035906 MetI-like superfamily
3 515 PANTHER PTHR30183 MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB
495 512 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 258 Gene3D G3DSA:1.10.3720.10 -
3 258 InterPro IPR035906 MetI-like superfamily
280 516 Gene3D G3DSA:1.10.3720.10 -
280 516 InterPro IPR035906 MetI-like superfamily
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
393 411 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
248 279 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
318 498 CDD cd06261 TM_PBP2
318 498 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
318 512 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
318 512 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
4 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
47 69 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
453 475 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
276 518 FunFam G3DSA:1.10.3720.10:FF:000048 Thiamine/thiamine pyrophosphate ABC transporter permease ThiP
452 475 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
321 341 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
495 512 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
115 137 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
36 44 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJ62
AlphaFold — — full sequence — Viewing
ColabFold VK055_2507
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.732
18 0.288
1 0.242
25 0.204

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.92 0.894
2 4.66 0.203
3 3.83 0.149
4 2.71 0.081
5 2.66 0.078