Protein profile

VK055_2558

na+/H+ antiporter NhaA

Genome: KpATCC43816

Gene: AIK81155.1 nhaA Structure source: AlphaFold + ColabFold UniProt A0A0H3GRG3
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Amino acids 391
Annotations 5
Features 45
PDB binders 0
Druggability 0.817

Overview

Basic information about this protein and its source genome.

Accession
VK055_2558
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81155.1 nhaA
Status
annotated
Amino acids
391
Structure source
AlphaFold + ColabFold
GO
GO:0006885 Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015385 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.013
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.817
Structure A0A0H3GRG3
Pocket Pocket 2
P2Rank 0.691
Structure A0A0H3GRG3
Pocket Pocket 1
ColabFold model
FPocket 0.96 · Pocket 1
P2Rank 0.675 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 156 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006885 Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006814 The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015385 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

Sequence Features

Domain/signature hits from InterPro and related databases.

45 records
Show feature table
Start End DB Term Name
7 380 NCBIfam TIGR00773 Na+/H+ antiporter NhaA
7 380 InterPro IPR004670 Na+/H+ antiporter NhaA
288 312 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
357 379 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
313 327 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
154 175 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
201 206 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
80 93 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
59 79 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 115 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 388 FunFam G3DSA:1.20.1530.10:FF:000001 Na(+)/H(+) antiporter NhaA
125 147 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
328 350 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 388 Hamap MF_01844 Na(+)/H(+) antiporter NhaA [nhaA].
4 388 InterPro IPR004670 Na+/H+ antiporter NhaA
181 200 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
154 176 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
146 153 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
363 380 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
207 237 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
328 351 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
352 362 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
215 237 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 385 PANTHER PTHR30341 SODIUM ION/PROTON ANTIPORTER NHAA-RELATED
2 385 InterPro IPR004670 Na+/H+ antiporter NhaA
40 58 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
381 391 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
277 287 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
176 180 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 387 Gene3D G3DSA:1.20.1530.10 Na+/H+ antiporter like domain
1 387 InterPro IPR023171 Na+/H+ antiporter domain superfamily
238 256 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
257 279 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
180 202 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
94 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
115 125 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 380 Pfam PF06965 Na+/H+ antiporter 1
6 380 InterPro IPR004670 Na+/H+ antiporter NhaA
286 308 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
257 276 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
126 145 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRG3
AlphaFold — — full sequence — Viewing
ColabFold VK055_2558
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.817
3 0.65
1 0.401

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.4 0.505
2 6.64 0.337
3 5.91 0.29
4 5.45 0.26
5 5.1 0.233

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

26 records

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Show only:
Ligand UniProt (homolog) pchembl MW · LogP · TPSA Lipinski PAINS SMILES
1PK P13738 6.10 183.2 Da LogP 2.21 TPSA 50.4 ✓ Ro5 Alert c1cc2cccc3c2c(c1)NC(=N3)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.