Protein profile

VK055_2579

creA family protein

Genome: KpATCC43816

Gene: AIK81176.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GIW8
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Amino acids 157
Annotations 1
Features 13
PDB binders 0
Druggability 0.76

Overview

Basic information about this protein and its source genome.

Accession
VK055_2579
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81176.1
Status
annotated
Amino acids
157
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.76
Structure A0A0H3GIW8
Pocket Pocket 1
P2Rank
Structure A0A0H3GIW8
Pocket No pockets
ColabFold model
FPocket 0.506 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 137 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
1 157 PIRSF PIRSF003174 CreA
1 157 InterPro IPR010292 Uncharacterised protein family CreA
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 156 PANTHER PTHR37952 -
7 156 InterPro IPR010292 Uncharacterised protein family CreA
22 157 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
14 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
24 155 Pfam PF05981 CreA protein
24 155 InterPro IPR010292 Uncharacterised protein family CreA
6 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GIW8
AlphaFold — — full sequence — Viewing
ColabFold VK055_2579
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.76