Protein profile

VK055_2597

patatin-like phospholipase family protein

Genome: KpATCC43816

Gene: AIK81194.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHY0
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Amino acids 357
Annotations 3
Features 13
PDB binders 0
Druggability 0.954

Overview

Basic information about this protein and its source genome.

Accession
VK055_2597
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81194.1
Status
annotated
Amino acids
357
Structure source
AlphaFold + ColabFold
GO
GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016042 The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
28.205
Localization
Unknown
ColabFold pLDDT
85.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.954
Structure A0A0H3GHY0
Pocket Pocket 20
P2Rank 0.937
Structure A0A0H3GHY0
Pocket Pocket 1
ColabFold model
FPocket 0.851 · Pocket 22
P2Rank 0.913 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 106 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0016042 The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
27 294 CDD cd07208 Pat_hypo_Ecoli_yjju_like
27 294 InterPro IPR037483 YjjU-like
23 301 PANTHER PTHR14226 NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER
115 218 Gene3D G3DSA:3.40.1090.10 Cytosolic phospholipase A2 catalytic domain
17 114 Gene3D G3DSA:3.40.1090.10 Cytosolic phospholipase A2 catalytic domain
21 279 SUPERFAMILY SSF52151 FabD/lysophospholipase-like
21 279 InterPro IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
27 195 Pfam PF01734 Patatin-like phospholipase
27 195 InterPro IPR002641 Patatin-like phospholipase domain
27 196 ProSiteProfiles PS51635 Patatin-like phospholipase (PNPLA) domain profile.
27 196 InterPro IPR002641 Patatin-like phospholipase domain
233 305 Pfam PF19890 Domain of unknown function (DUF6363)
233 305 InterPro IPR045943 Domain of unknown function DUF6363

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHY0
AlphaFold — — full sequence — Viewing
ColabFold VK055_2597
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.954
1 0.539

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 25.52 0.907
2 4.09 0.165
3 2.12 0.049