Protein profile

VK055_2616

bacterial regulatory helix-turn-helix, AraC family protein

Genome: KpATCC43816

Gene: AIK81210.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRB4
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Amino acids 293
Annotations 3
Features 18
PDB binders 0
Druggability 0.738

Overview

Basic information about this protein and its source genome.

Accession
VK055_2616
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81210.1
Status
annotated
Amino acids
293
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
34.589
Localization
Cytoplasmic
ColabFold pLDDT
88.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.738
Structure A0A0H3GRB4
Pocket Pocket 2
P2Rank 0.142
Structure A0A0H3GRB4
Pocket Pocket 1
ColabFold model
FPocket 0.866 · Pocket 2
P2Rank 0.289 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
208 286 Pfam PF12833 Helix-turn-helix domain
208 286 InterPro IPR018060 DNA binding HTH domain, AraC-type
7 104 CDD cd06999 cupin_HpaA-like_N
7 104 InterPro IPR047264 HpaA-like, N-terminal cupin domain
202 285 SMART SM00342 aracneu4
202 285 InterPro IPR018060 DNA binding HTH domain, AraC-type
254 269 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
254 269 InterPro IPR020449 Transcription regulator HTH, AraC- type
269 285 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
269 285 InterPro IPR020449 Transcription regulator HTH, AraC- type
27 290 PANTHER PTHR43280 ARAC-FAMILY TRANSCRIPTIONAL REGULATOR
240 288 SUPERFAMILY SSF46689 Homeodomain-like
240 288 InterPro IPR009057 Homeobox-like domain superfamily
181 289 Gene3D G3DSA:1.10.10.60 -
41 116 SUPERFAMILY SSF51182 RmlC-like cupins
41 116 InterPro IPR011051 RmlC-like cupin domain superfamily
189 287 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
189 287 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRB4
AlphaFold — — full sequence — Viewing
ColabFold VK055_2616
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.738
5 0.529
11 0.291

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.88 0.037
2 1.79 0.033
3 1.34 0.015
4 1.29 0.014
5 1.2 0.01