Protein profile

VK055_2635

putative DNA-binding transcriptional regulator

Genome: KpATCC43816

Gene: AIK81229.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHV2
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Amino acids 304
Annotations 3
Features 21
PDB binders 0
Druggability 0.921

Overview

Basic information about this protein and its source genome.

Accession
VK055_2635
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81229.1
Status
annotated
Amino acids
304
Structure source
AlphaFold + ColabFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.35

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.921
Structure A0A0H3GHV2
Pocket Pocket 1
P2Rank 0.707
Structure A0A0H3GHV2
Pocket Pocket 1
ColabFold model
FPocket 0.821 · Pocket 1
P2Rank 0.848 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 42 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
89 147 Gene3D G3DSA:1.10.10.10 -
89 147 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
3 62 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
3 62 InterPro IPR036390 Winged helix DNA-binding domain superfamily
93 147 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
93 147 InterPro IPR036390 Winged helix DNA-binding domain superfamily
155 301 Gene3D G3DSA:1.20.120.530 -
155 301 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
159 286 Pfam PF07729 FCD domain
159 286 InterPro IPR011711 GntR, C-terminal
159 287 SMART SM00895 FCD_2
159 287 InterPro IPR011711 GntR, C-terminal
98 298 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
158 294 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
158 294 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
42 58 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
42 58 InterPro IPR000524 Transcription regulator HTH, GntR
28 42 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
28 42 InterPro IPR000524 Transcription regulator HTH, GntR
1 67 Gene3D G3DSA:1.10.10.10 -
1 67 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHV2
AlphaFold — — full sequence — Viewing
ColabFold VK055_2635
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.921