Protein profile

VK055_2668

hypothetical protein

Genome: KpATCC43816

Gene: AIK81262.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHS4
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Amino acids 308
Annotations 2
Features 5
PDB binders 0
Druggability 0.98

Overview

Basic information about this protein and its source genome.

Accession
VK055_2668
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81262.1
Status
annotated
Amino acids
308
Structure source
AlphaFold + ColabFold
GO
GO:1990238 Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
62.376
DEG E-value
9.88e-139
Localization
Cytoplasmic
ColabFold pLDDT
87.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.98
Structure A0A0H3GHS4
Pocket Pocket 1
P2Rank 0.331
Structure A0A0H3GHS4
Pocket Pocket 1
ColabFold model
FPocket 0.749 · Pocket 2
P2Rank 0.352 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:1990238 Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
8 209 Pfam PF04754 Putative transposase, YhgA-like
8 209 InterPro IPR006842 Transposase (putative), YhgA-like
9 304 NCBIfam TIGR01784 Rpn family recombination-promoting nuclease/putative transposase
9 304 InterPro IPR010106 Recombination-promoting nuclease RpnA
1 308 PANTHER PTHR34611 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHS4
AlphaFold — — full sequence — Viewing
ColabFold VK055_2668
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.98
12 0.305

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.4 0.185
2 2.5 0.069
3 1.93 0.04
4 1.57 0.024
5 1.3 0.014