Protein profile

VK055_2706

periplasmic copper/silver-binding protein

Genome: KpATCC43816

Gene: cusF AIK81296.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLY6
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Amino acids 114
Annotations 0
Features 11
PDB binders 0
Druggability 0.183

Overview

Basic information about this protein and its source genome.

Accession
VK055_2706
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
cusF AIK81296.1
Status
annotated
Amino acids
114
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.464
DEG E-value
9.91e-38
Localization
Periplasmic
ColabFold pLDDT
81.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.183
Structure A0A0H3GLY6
Pocket Pocket 1
P2Rank
Structure A0A0H3GLY6
Pocket No pockets
ColabFold model
FPocket 0.26 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
47 109 Pfam PF11604 Copper binding periplasmic protein CusF
47 109 InterPro IPR021647 Copper binding periplasmic protein CusF
41 114 Gene3D G3DSA:2.40.50.320 Copper binding periplasmic protein CusF
41 114 InterPro IPR042230 Copper binding periplasmic protein CusF superfamily
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
23 114 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLY6
AlphaFold — — full sequence — Viewing
ColabFold VK055_2706
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer