Protein profile

VK055_2725

HNH endonuclease family protein

Genome: KpATCC43816

Gene: AIK81315.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLW7
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Amino acids 212
Annotations 3
Features 5
PDB binders 0
Druggability 0.643

Overview

Basic information about this protein and its source genome.

Accession
VK055_2725
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81315.1
Status
annotated
Amino acids
212
Structure source
AlphaFold + ColabFold
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
80.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.643
Structure A0A0H3GLW7
Pocket Pocket 12
P2Rank 0.177
Structure A0A0H3GLW7
Pocket Pocket 1
ColabFold model
FPocket 0.673 · Pocket 14
P2Rank 0.19 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
130 193 CDD cd00085 HNHc
130 193 InterPro IPR003615 HNH nuclease
107 209 Gene3D G3DSA:1.10.30.50 -
139 195 Pfam PF01844 HNH endonuclease
139 195 InterPro IPR002711 HNH endonuclease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLW7
AlphaFold — — full sequence — Viewing
ColabFold VK055_2725
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.106
11 0.078
16 0.013
14 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.83 0.177
2 2.35 0.05