Protein profile

VK055_2729

integrase core domain protein

Genome: KpATCC43816

Gene: AIK81319.1 Structure source: AlphaFold + ColabFold UniProt A0A486VK46
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Amino acids 109
Annotations 2
Features 10
PDB binders 0
Druggability 0.083

Overview

Basic information about this protein and its source genome.

Accession
VK055_2729
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81319.1
Status
annotated
Amino acids
109
Structure source
AlphaFold + ColabFold
GO
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.98
DEG E-value
6.15e-35
Localization
Unknown
ColabFold pLDDT
88.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.083
Structure A0A486VK46
Pocket Pocket 4
P2Rank
Structure A0A486VK46
Pocket No pockets
ColabFold model
FPocket 0.288 · Pocket 13
P2Rank 0.017 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
  • GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
4 107 PANTHER PTHR47515 LOW CALCIUM RESPONSE LOCUS PROTEIN T
68 88 Coils Coil Coil
30 96 Pfam PF13683 Integrase core domain
30 96 InterPro IPR001584 Integrase, catalytic core
2 107 Gene3D G3DSA:3.30.420.10 -
2 107 InterPro IPR036397 Ribonuclease H superfamily
1 104 ProSiteProfiles PS50994 Integrase catalytic domain profile.
1 104 InterPro IPR001584 Integrase, catalytic core
3 101 SUPERFAMILY SSF53098 Ribonuclease H-like
3 101 InterPro IPR012337 Ribonuclease H-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A486VK46
AlphaFold — — full sequence — Viewing
ColabFold VK055_2729
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer