Protein profile

VK055_2731

transposase family protein

Genome: KpATCC43816

Gene: AIK81321.1 Structure source: AlphaFold + ColabFold UniProt A0ABD7NTS0
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Amino acids 88
Annotations 3
Features 6
PDB binders 0
Druggability 0.214

Overview

Basic information about this protein and its source genome.

Accession
VK055_2731
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81321.1
Status
annotated
Amino acids
88
Structure source
AlphaFold + ColabFold
GO
GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.318
DEG E-value
6.01e-23
Localization
Cytoplasmic
ColabFold pLDDT
89.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.214
Structure A0ABD7NTS0
Pocket Pocket 3
P2Rank
Structure A0ABD7NTS0
Pocket No pockets
ColabFold model
FPocket 0.736 · Pocket 1
P2Rank 0.066 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 28 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
2 70 Pfam PF01527 Transposase
2 70 InterPro IPR002514 Transposase IS3/IS911family
1 87 PANTHER PTHR33609 LOW CALCIUM RESPONSE LOCUS PROTEIN S
56 76 Coils Coil Coil
1 71 SUPERFAMILY SSF46689 Homeodomain-like
1 71 InterPro IPR009057 Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0ABD7NTS0
AlphaFold — — full sequence — Viewing
ColabFold VK055_2731
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.214