Protein profile

VK055_2746

KAP family P-loop domain protein

Genome: KpATCC43816

Gene: AIK81336.1 Structure source: AlphaFold + ColabFold UniProt A0A422ZFZ3
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Amino acids 591
Annotations 0
Features 7
PDB binders 0
Druggability 0.67

Overview

Basic information about this protein and its source genome.

Accession
VK055_2746
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81336.1
Status
annotated
Amino acids
591
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
82.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.67
Structure A0A422ZFZ3
Pocket Pocket 14
P2Rank 0.762
Structure A0A422ZFZ3
Pocket Pocket 1
ColabFold model
FPocket 0.946 · Pocket 26
P2Rank 0.757 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
16 257 Gene3D G3DSA:3.40.50.300 -
16 257 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
198 386 PANTHER PTHR22674 NTPASE, KAP FAMILY P-LOOP DOMAIN-CONTAINING 1
36 392 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
36 392 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
19 381 Pfam PF07693 KAP family P-loop domain
19 381 InterPro IPR011646 KAP family P-loop domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A422ZFZ3
AlphaFold — — full sequence — Viewing
ColabFold VK055_2746
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.67
23 0.627
1 0.007
13 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.84 0.762
2 13.03 0.589
3 8.32 0.378
4 3.99 0.129
5 3.34 0.094