Protein profile

VK055_2748

4Fe-4S single cluster domain protein

Genome: KpATCC43816

Gene: AIK81338.1 Structure source: AlphaFold + ColabFold UniProt A0A422ZFZ0
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Amino acids 462
Annotations 3
Features 12
PDB binders 0
Druggability 0.807

Overview

Basic information about this protein and its source genome.

Accession
VK055_2748
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81338.1
Status
annotated
Amino acids
462
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.428
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.807
Structure A0A422ZFZ0
Pocket Pocket 2
P2Rank 0.932
Structure A0A422ZFZ0
Pocket Pocket 1
ColabFold model
FPocket 0.88 · Pocket 9
P2Rank 0.965 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
3 460 NCBIfam TIGR03978 His-Xaa-Ser system radical SAM maturase HxsB
3 460 InterPro IPR024023 His-Xaa-Ser system radical SAM maturase HxsB
86 447 SFLD SFLDG01384 thioether bond formation requiring two auxiliary iron-sulfur clusters
86 447 InterPro IPR023867 Anaerobic sulphatase maturase, radical SAM
85 409 PANTHER PTHR43273 ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED
85 409 InterPro IPR023867 Anaerobic sulphatase maturase, radical SAM
88 287 CDD cd01335 Radical_SAM
87 409 SUPERFAMILY SSF102114 Radical SAM enzymes
94 174 Pfam PF13353 4Fe-4S single cluster domain
85 448 Gene3D G3DSA:3.20.20.70 Aldolase class I
85 448 InterPro IPR013785 Aldolase-type TIM barrel
86 447 SFLD SFLDG01067 SPASM/twitch domain containing

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A422ZFZ0
AlphaFold — — full sequence — Viewing
ColabFold VK055_2748
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.807
8 0.582

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 20.05 0.849
2 16.36 0.777
3 4.13 0.167
4 3.01 0.099
5 2.09 0.047