Protein profile

VK055_2750

SIR2-like domain protein

Genome: KpATCC43816

Gene: AIK81340.1 Structure source: AlphaFold + ColabFold UniProt A0A423A1T4
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Amino acids 555
Annotations 0
Features 4
PDB binders 0
Druggability 0.664

Overview

Basic information about this protein and its source genome.

Accession
VK055_2750
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81340.1
Status
annotated
Amino acids
555
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
29.276
Localization
Cytoplasmic
ColabFold pLDDT
82.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.664
Structure A0A423A1T4
Pocket Pocket 16
P2Rank 0.591
Structure A0A423A1T4
Pocket Pocket 1
ColabFold model
FPocket 0.612 · Pocket 1
P2Rank 0.885 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
41 554 PIRSF PIRSF014677 UCP014677
41 554 InterPro IPR011202 Uncharacterised conserved protein UCP014677
172 297 Pfam PF13289 SIR2-like domain
172 297 InterPro IPR039444 SIR2-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A423A1T4
AlphaFold — — full sequence — Viewing
ColabFold VK055_2750
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.643
35 0.157
18 0.005
21 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.08 0.591
2 10.42 0.482
3 6.43 0.272
4 3.45 0.099
5 3.26 0.09