Protein profile

VK055_2758

putative conserved DNA-binding protein

Genome: KpATCC43816

Gene: AIK81348.1 Structure source: ColabFold
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Amino acids 543
Annotations 1
Features 3
PDB binders 0
Druggability 0.849

Overview

Basic information about this protein and its source genome.

Accession
VK055_2758
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81348.1
Status
annotated
Amino acids
543
Structure source
ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
96.317
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
82.76

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.849
Structure CB_VK055_2758
Pocket Pocket 2
P2Rank 0.189
Structure CB_VK055_2758
Pocket Pocket 1
ColabFold model
FPocket 0.849 · Pocket 2
P2Rank 0.189 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

3 records
Show feature table
Start End DB Term Name
277 297 Coils Coil Coil
209 441 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
209 441 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_2758
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.849
29 0.8
23 0.379
18 0.25

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.95 0.223
2 3.39 0.121
3 3.14 0.106
4 2.74 0.083
5 1.76 0.032