Protein profile

VK055_2759

phage integrase family protein

Genome: KpATCC43816

Gene: AIK81349.1 Structure source: ColabFold
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Amino acids 436
Annotations 3
Features 8
PDB binders 0
Druggability 0.495

Overview

Basic information about this protein and its source genome.

Accession
VK055_2759
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81349.1
Status
annotated
Amino acids
436
Structure source
ColabFold
GO
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
89.45
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.94

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.495
Structure CB_VK055_2759
Pocket Pocket 14
P2Rank 0.659
Structure CB_VK055_2759
Pocket Pocket 1
ColabFold model
FPocket 0.495 · Pocket 14
P2Rank 0.659 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
151 384 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
151 384 InterPro IPR013762 Integrase-like, catalytic domain superfamily
153 380 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
153 380 InterPro IPR002104 Integrase, catalytic domain
158 371 Pfam PF00589 Phage integrase family
158 371 InterPro IPR002104 Integrase, catalytic domain
62 374 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
62 374 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_2759
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.495
1 0.013
33 0.004
18 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.0 0.659
2 7.63 0.339
3 2.06 0.038
4 2.03 0.037
5 0.84 0.003