Protein profile

VK055_2767

carbonic anhydrase 2

Genome: KpATCC43816

Gene: AIK81356.1 yadF2 Structure source: AlphaFold + ColabFold UniProt A0A483P2C6
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Amino acids 226
Annotations 6
Features 15
PDB binders 5
Druggability 0.336

Overview

Basic information about this protein and its source genome.

Accession
VK055_2767
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81356.1 yadF2
Status
annotated
Amino acids
226
Structure source
AlphaFold + ColabFold
EC
4.2.1.1
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0015976 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0004089 Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. GO:0071244 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.465
DEG E-value
1.35e-47
Localization
Cytoplasmic
ColabFold pLDDT
92.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.336
Structure A0A483P2C6
Pocket Pocket 8
P2Rank 0.288
Structure A0A483P2C6
Pocket Pocket 1
ColabFold model
FPocket 0.663 · Pocket 1
P2Rank 0.125 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 19 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0015976 A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism.
  • GO:0004089 Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.
  • GO:0071244 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.
  • GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
11 215 CDD cd00883 beta_CA_cladeA
42 49 ProSitePatterns PS00704 Prokaryotic-type carbonic anhydrases signature 1.
42 49 InterPro IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site
30 216 SMART SM00947 Pro_CA_2
30 216 InterPro IPR001765 Carbonic anhydrase
38 211 Pfam PF00484 Carbonic anhydrase
38 211 InterPro IPR001765 Carbonic anhydrase
82 102 ProSitePatterns PS00705 Prokaryotic-type carbonic anhydrases signature 2.
82 102 InterPro IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site
2 215 SUPERFAMILY SSF53056 beta-carbonic anhydrase, cab
2 215 InterPro IPR036874 Carbonic anhydrase superfamily
3 216 PANTHER PTHR11002 CARBONIC ANHYDRASE
3 216 InterPro IPR001765 Carbonic anhydrase
1 223 Gene3D G3DSA:3.40.1050.10 Carbonic anhydrase
1 223 InterPro IPR036874 Carbonic anhydrase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483P2C6
AlphaFold — — full sequence — Viewing
ColabFold VK055_2767
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.014
1 0.002
9 0.0
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.72 0.288
2 2.0 0.036
3 0.72 0.002

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

155 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4MZ
6D2O
Q9HVB9 82.1 Da LogP 0.72 TPSA 28.7 ✓ Ro5 ✓ Clean Cc1c[nH]cn1
AZI
3UCN
Q96554 42.0 Da LogP 0.87 TPSA 58.7 ✓ Ro5 Alert [N-]=[N+]=[N-]
AZM
3UCJ
Q96554 222.3 Da LogP -0.86 TPSA 115.0 ✓ Ro5 ✓ Clean CC(=O)Nc1nnc(s1)S(=O)(=O)N
CO2
5BQ1
Q9HVB9 44.0 Da LogP -0.58 TPSA 34.1 ✓ Ro5 ✓ Clean C(=O)=O
FUS
6D2N
Q9HVB9 96.1 Da LogP -1.85 TPSA 86.2 ✓ Ro5 ✓ Clean NS(=O)(=O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.