Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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11 proteins

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Sorted by Druggability (descending)

Applied filters EC Number: 4.2.1.1

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EC Number: 4.2.1.1 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_0082 phosphogluconate dehydratase edd AlphaFold + ColabFold
4.2.1.12
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004456Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O. GO:0009255A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. +58 total
0.725 No Hit 0.0% —
2 VK055_4391 phosphopyruvate hydratase eno AlphaFold + ColabFold
4.2.1.11
GO:0000015A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. GO:0000287Binding to a magnesium (Mg) ion. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. +36 total
0.651 Hit 61.6% 4.81e-49
3 VK055_4856 o-succinylbenzoate synthase menC AlphaFold + ColabFold
4.2.1.113
GO:0000287Binding to a magnesium (Mg) ion. GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. +14 total
0.619 No Hit 0.0% —
4 VK055_0331 xylose isomerase-like TIM barrel family protein AlphaFold + ColabFold
4.2.1.118
GO:0046565Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. GO:0046279The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. +14 total
0.6 Hit 26.4% 2.18e-07
5 VK055_1899 methylthioribulose-1-phosphate dehydratase mtnB AlphaFold + ColabFold
4.2.1.109
GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +58 total
0.583 Hit 24.7% 2.37e-10
6 VK055_3423 N-acetylmuramic acid 6-phosphate etherase murQ AlphaFold + ColabFold
4.2.1.126
GO:0046348The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. GO:0016835Catalysis of the breakage of a carbon-oxygen bond. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. +58 total
0.45 Hit 23.3% 3.64e-07
7 VK055_2500 3-dehydroquinate dehydratase aroD AlphaFold + ColabFold
4.2.1.10
GO:0003855Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. GO:0046279The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. +25 total
0.39 No Hit 0.0% —
8 VK055_3813 3-dehydroquinate dehydratase, type II aroQ AlphaFold + ColabFold
4.2.1.10
GO:0003855Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +25 total
0.369 No Hit 0.0% —
9 VK055_2767 carbonic anhydrase 2 yadF2 AlphaFold + ColabFold
4.2.1.1
GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. +25 total
0.336 No Hit 0.0% —
10 VK055_2434 carbonic anhydrase 2 yadF AlphaFold + ColabFold
4.2.1.1
GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.
0.175 No Hit 0.0% —
11 VK055_0461 carbonate dehydratase carbonic anhydrase cynT AlphaFold + ColabFold
4.2.1.1
GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.
0.095 No Hit 0.0% —
Page 1 of 1 · 11 total proteins