Protein profile

VK055_2770

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK81359.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQY6
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Amino acids 290
Annotations 3
Features 32
PDB binders 0
Druggability 0.881

Overview

Basic information about this protein and its source genome.

Accession
VK055_2770
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81359.1
Status
annotated
Amino acids
290
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
34.52
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.881
Structure A0A0H3GQY6
Pocket Pocket 4
P2Rank 0.072
Structure A0A0H3GQY6
Pocket Pocket 1
ColabFold model
FPocket 0.925 · Pocket 3
P2Rank 0.122 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 15 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
223 261 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 288 PANTHER PTHR30193 ABC TRANSPORTER PERMEASE PROTEIN
152 174 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
197 222 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
49 277 SUPERFAMILY SSF161098 MetI-like
49 277 InterPro IPR035906 MetI-like superfamily
45 286 Gene3D G3DSA:1.10.3720.10 -
45 286 InterPro IPR035906 MetI-like superfamily
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
177 196 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
152 176 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
69 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
65 278 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
65 278 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
9 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
102 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 251 CDD cd06261 TM_PBP2
93 251 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
30 68 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
262 282 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 101 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
260 282 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
125 151 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
79 277 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
79 277 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
203 225 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
69 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
283 290 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQY6
AlphaFold — — full sequence — Viewing
ColabFold VK055_2770
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.881
5 0.833
21 0.265

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.93 0.04
2 1.84 0.035
3 1.38 0.017
4 1.27 0.013