Protein profile

VK055_2785

putative transposase

Genome: KpATCC43816

Gene: AIK81374.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRH9
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Amino acids 261
Annotations 2
Features 14
PDB binders 0
Druggability 0.019

Overview

Basic information about this protein and its source genome.

Accession
VK055_2785
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81374.1
Status
annotated
Amino acids
261
Structure source
AlphaFold + ColabFold
GO
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.388
DEG E-value
3.14e-92
Localization
Unknown
ColabFold pLDDT
88.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.019
Structure A0A0H3GRH9
Pocket Pocket 2
P2Rank 0.236
Structure A0A0H3GRH9
Pocket Pocket 1
ColabFold model
FPocket 0.274 · Pocket 17
P2Rank 0.384 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 184 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
  • GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
94 254 Gene3D G3DSA:3.30.420.10 -
94 254 InterPro IPR036397 Ribonuclease H superfamily
99 196 Pfam PF00665 Integrase core domain
99 196 InterPro IPR001584 Integrase, catalytic core
203 258 Pfam PF13333 Integrase core domain
203 258 InterPro IPR001584 Integrase, catalytic core
1 254 NCBIfam NF033516 IS3 family transposase
84 258 ProSiteProfiles PS50994 Integrase catalytic domain profile.
84 258 InterPro IPR001584 Integrase, catalytic core
1 256 PANTHER PTHR46889 TRANSPOSASE INSF FOR INSERTION SEQUENCE IS3B-RELATED
93 252 SUPERFAMILY SSF53098 Ribonuclease H-like
93 252 InterPro IPR012337 Ribonuclease H-like superfamily
22 75 Pfam PF13276 HTH-like domain
22 75 InterPro IPR025948 HTH-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRH9
AlphaFold — — full sequence — Viewing
ColabFold VK055_2785
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.76 0.145
2 2.41 0.065
3 2.13 0.049