Protein profile

VK055_2888

hypothetical protein

Genome: KpATCC43816

Gene: AIK81477.1 Structure source: AlphaFold + ColabFold UniProt A0A377XIN3
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Amino acids 82
Annotations 0
Features 11
PDB binders 0
Druggability 0.606

Overview

Basic information about this protein and its source genome.

Accession
VK055_2888
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81477.1
Status
annotated
Amino acids
82
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
41.509
Localization
CytoplasmicMembrane
ColabFold pLDDT
81.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.606
Structure A0A377XIN3
Pocket Pocket 4
P2Rank
Structure A0A377XIN3
Pocket No pockets
ColabFold model
FPocket 0.352 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 98 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 21 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
41 60 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20 79 PANTHER PTHR38602 INNER MEMBRANE PROTEIN-RELATED
20 79 InterPro IPR019201 Protein of unknown function DUF2065
22 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
26 76 Pfam PF09838 Uncharacterized protein conserved in bacteria (DUF2065)
26 76 InterPro IPR019201 Protein of unknown function DUF2065
78 82 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
61 77 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377XIN3
AlphaFold — — full sequence — Viewing
ColabFold VK055_2888
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.606
3 0.481
2 0.174
1 0.128