Protein profile

VK055_2922

hlyD secretion family protein

Genome: KpATCC43816

Gene: AIK81508.1 Structure source: AlphaFold + ColabFold UniProt A0A483K745
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Amino acids 428
Annotations 3
Features 19
PDB binders 0
Druggability 0.583

Overview

Basic information about this protein and its source genome.

Accession
VK055_2922
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81508.1
Status
annotated
Amino acids
428
Structure source
AlphaFold + ColabFold
GO
GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
39.43
Localization
Unknown
ColabFold pLDDT
89.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.583
Structure A0A483K745
Pocket Pocket 16
P2Rank
Structure A0A483K745
Pocket No pockets
ColabFold model
FPocket 0.451 · Pocket 10
P2Rank 0.009 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
309 333 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
80 100 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
275 296 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
83 401 Pfam PF00529 Cation efflux system protein CusB domain 1
83 401 InterPro IPR043602 Cation efflux system protein CusB, domain 1
239 342 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
239 342 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
277 403 Gene3D G3DSA:2.40.30.170 -
21 50 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
232 259 Coils Coil Coil
51 428 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
390 412 ProSitePatterns PS00543 HlyD family secretion proteins signature.
390 412 InterPro IPR006144 Secretion protein HlyD, conserved site
67 104 SUPERFAMILY SSF51230 Single hybrid motif
67 104 InterPro IPR011053 Single hybrid motif
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 147 Gene3D G3DSA:2.40.50.100 -
32 405 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483K745
AlphaFold — — full sequence — Viewing
ColabFold VK055_2922
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.023
7 0.004
18 0.002
13 0.001