Protein profile

VK055_2927

type VII secretion system (T7SS), usher family protein

Genome: KpATCC43816

Gene: AIK81513.1 Structure source: AlphaFold + ColabFold UniProt A0A483EXH1
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Amino acids 856
Annotations 5
Features 27
PDB binders 0
Druggability 0.137

Overview

Basic information about this protein and its source genome.

Accession
VK055_2927
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81513.1
Status
annotated
Amino acids
856
Structure source
AlphaFold + ColabFold
GO
GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
39.043
Localization
OuterMembrane
ColabFold pLDDT
86.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.137
Structure A0A483EXH1
Pocket Pocket 37
P2Rank 0.074
Structure A0A483EXH1
Pocket Pocket 1
ColabFold model
FPocket 0.199 · Pocket 63
P2Rank 0.434 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005515 Binding to a protein.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
205 762 Pfam PF00577 Outer membrane usher protein
205 762 InterPro IPR000015 Outer membrane usher protein
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
678 768 FunFam G3DSA:2.60.40.2610:FF:000001 Outer membrane fimbrial usher protein
277 366 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
21 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
10 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
29 856 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 855 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
2 855 InterPro IPR000015 Outer membrane usher protein
769 856 Gene3D G3DSA:2.60.40.2070 -
769 856 InterPro IPR043142 PapC-like, C-terminal domain superfamily
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
277 366 Gene3D G3DSA:2.60.40.3110 -
56 178 SUPERFAMILY SSF141729 FimD N-terminal domain-like
56 178 InterPro IPR037224 PapC, N-terminal domain superfamily
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
319 329 ProSitePatterns PS01151 Fimbrial biogenesis outer membrane usher protein signature.
319 329 InterPro IPR018030 Fimbrial membrane usher, conserved site
48 175 Gene3D G3DSA:3.10.20.410 -
48 175 InterPro IPR037224 PapC, N-terminal domain superfamily
32 187 Pfam PF13954 PapC N-terminal domain
32 187 InterPro IPR025885 PapC, N-terminal domain
772 840 Pfam PF13953 PapC C-terminal domain
772 840 InterPro IPR025949 PapC-like, C-terminal domain
679 768 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
679 768 InterPro IPR042186 Outer membrane usher protein FimD, plug domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483EXH1
AlphaFold — — full sequence — Viewing
ColabFold VK055_2927
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.84 0.036
2 1.01 0.006
3 0.99 0.005
4 0.95 0.005
5 0.91 0.004