Protein profile

VK055_2934

fxsA cytoplasmic membrane family protein

Genome: KpATCC43816

Gene: AIK81520.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQF5
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Amino acids 158
Annotations 1
Features 14
PDB binders 0
Druggability 0.945

Overview

Basic information about this protein and its source genome.

Accession
VK055_2934
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81520.1
Status
annotated
Amino acids
158
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
28.169
Localization
CytoplasmicMembrane
ColabFold pLDDT
79.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.945
Structure A0A0H3GQF5
Pocket Pocket 5
P2Rank 0.002
Structure A0A0H3GQF5
Pocket Pocket 1
ColabFold model
FPocket 0.705 · Pocket 15
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 111 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
8 111 Pfam PF04186 FxsA cytoplasmic membrane protein
8 111 InterPro IPR007313 FxsA cytoplasmic membrane protein
26 48 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 149 PANTHER PTHR35335 UPF0716 PROTEIN FXSA
1 149 InterPro IPR007313 FxsA cytoplasmic membrane protein
102 158 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
78 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 77 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
130 158 MobiDBLite mobidb-lite consensus disorder prediction
12 38 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
137 158 MobiDBLite mobidb-lite consensus disorder prediction
79 101 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQF5
AlphaFold — — full sequence — Viewing
ColabFold VK055_2934
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.945
2 0.455
3 0.253